Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is associated with metabolic disorders such as insulin resistance, hyperinsulinemia, dyslipidemia and central obesity which increase the risk of cardiovascular diseases (CVD). Lipid accumulation product (LAP) and waist circumference to height ratio (WHtR) are novel CVD risk predictors based on the assessment of waist circumference, height and serum triglycerides. The aim of our study was to evaluate the LAP and WHtR associations w...

Neurofibromatosis 1 (NF1) is a rare disease determined by mutations in the RAS-MAPK pathway. It can cause precocious or delayed puberty.Case 1: A 11 years 9 months old girl known with Neurofibromatosis – Noonan Syndrome (NF-NS) was admitted for severe growth deficit (-5.14 SDS). She had over 20 café au lait spots, hypertelorism, pterigium colli, B1 P1. At 18 months she had had surgery for pulmonary stenosis and after that a left ventricular tum...

Introduction: Synovial sarcoma represents a type of cancer derived from soft tissues; young males are more affected.Material and methods: This is a case report of a male with a cervical mass confirmed as sarcoma. Later on the investigations lead to the discovery of a thyroid nodule challenging the differential diagnosis. We assessed thyroid ultrasound, computed tomography (CT) at the cervical, thorax, mediastinum and abdomen; TSH (Thyroid Stimulating Hor...

Introduction: BRAF V600E mutation is reported to occur in 28–83% of papillary thyroid cancer, being associated with increased tumour aggressiveness.Objective: To determine the prevalence of BRAF V600E mutation in Romanian patients with thyroid nodules referred to surgery in a reference endocrinology centre.Materials and methods: 140 patients were included in the study: 70 patients with papillary thyroid carcinoma (PTC), 42 pat...

Background: Life expectancy of cancer survivors has doubled in the past four decades; however, death due to cardiovascular disease is more prevalent in survivors than the general population.Objective, design and methods: We evaluated novel and traditional cardiometabolic risk factors in young male cancer survivors in a cross-sectional study of male cancer survivors aged 25–45 years compared with age-matched non-cancer controls. Demographic and anthr...

Introduction: MEN1 is a rare syndrome characterised by hyperplasia or neoplasm of the parathyroid glands, pituitary, pancreas or duodenum and can associate, less frequently, phaeochromocytoma, thymic or bronchial carcinoids, multiple lipomas, cutaneous angiofibromas and thyroid adenomas.Case report: A 47-year-old woman with MEN1 presenting parathyroid recurrent adenomas, a pituitary prolactin-growth hormone cosecreting macroadenoma, associated with an in...

Given the increasing incidence in psychiatric pathology, adverse reactions of psychotropic medications, especially the metabolic and endocrine side effects, are encountered more frequently in clinical practice. We present the cases of two female patients with psychiatric pathology, in whom the specific treatment was accompanied by significant endocrine adverse reactions, making the tumoural differential diagnosis very difficult. The first case is of a patient aged 61 years, kn...

Introduction: We should consider testing for primary aldosteronism in the presence of hypertension and hypokalaemia, resistant hypertension, onset of hypertension at a young age (<20 year), severe hypertension and whenever considering secondary hypertension.Case report: We presented the case of a 38 years old woman who was admitted in the National Institute of Endocrinology C.I. Parhon Bucharest for the evaluation of high blood pressure. She has high...

Catecholamines can cause hypertension by increasing heart rate and cardiac output or by peripheral vasoconstriction.Aim of study: The value of plasma and urinary metanephrines and normetanephrines does not correlate with blood pressure in pheochromocytomas.Material and methods: The lot of study consist of 35 patients with isolated pheochromocytomas diagnosed between 1985 and 2005 in National Institute of Endocrinology C.I.Parhon Bu...

Introduction: The new tool FRAX indicated risk of fracture, using or not DXA which is the golden standard for osteoporosis diagnosis.Aim: We analyzed the lumbar DXA correlations with 10-year fragility fracture risk probability.Material and method: A cross sectional study in postmenopausal women was designed. They were osteoporosis free at baseline; none of them has previously been treated for osteoporosis. The anamnesis, the anthro...